Plasma Proteomic Profile of Patients with Tick-Borne Encephalitis and Co-Infections.

ABSTRACT: Despite the increasing number of patients suffering from tick-borne encephalitis (TBE), Lyme disease, and their co-infection, the mechanisms of the development of these diseases and their effects on the human body are still unknown. Therefore, the aim of this study was to evaluate the changes in the proteomic profile of human plasma induced by the development of TBE and to compare it with changes in TBE patients co-infected with other tick-borne pathogens. The results obtained by proteomic analysis using a nanoLC-Q Exactive HF mass spectrometer showed that the most highly elevated groups of proteins in the plasma of TBE patients with co-infection were involved in the pro-inflammatory response and protein degradation, while the antioxidant proteins and factors responsible for protein biosyn

SUBMITTER: Gegotek A 

PROVIDER: S-EPMC9031133 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature