Real World Estimate of Vaccination Protection in Individuals Hospitalized for COVID-19.

ABSTRACT: Whether vaccination confers a protective effect against progression after hospital admission for COVID-19 remains to be elucidated. Observational study including all the patients admitted to San Paolo Hospital in Milan for COVID-19 in 2021. Previous vaccination was categorized as: none, one dose, full vaccination (two or three doses >14 days before symptoms onset). Data were collected at hospital admission, including demographic and clinical variables, age-unadjusted Charlson Comorbidity index (CCI). The highest intensity of ventilation during hospitalization was registered. The endpoints were in-hospital death (primary) and mechanical ventilation/death (secondary). Survival analysis was conducted by means of Kaplan-Meier curves and Cox regression models. Effect measure modification by age

SUBMITTER: d'Arminio Monforte A 

PROVIDER: S-EPMC9031136 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature