Influenza Vaccination Effectiveness in Paediatric 'Healthy' Patients: A Population-Based Study in Italy.

ABSTRACT: Seasonal influenza can cause serious morbidity, mortality, and financial burden in pediatric and adult populations. The influenza vaccine (IV) is considered the most effective way to prevent influenza and influenza-like-illness (ILI) complications. To assess the effectiveness of the IV in a cohort of healthy children in Italy. From the Pedianet database, all healthy children aged six months-14 years between 2009-2019 were enrolled. Cox proportional-hazards models were fitted to estimate hazard ratios and the 95% confidence interval for the association between IV exposure during each season of interest (from October to April of each year) with incident influenza/ILI. Exposure was considered as a time-varying variable. Vaccine effectiveness (VE) was calculated as (1-HR) × 100. The additive a

SUBMITTER: Cantarutti A 

PROVIDER: S-EPMC9031219 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature