Enhanced In Vitro Antiviral Activity of Hydroxychloroquine Ionic Liquids against SARS-CoV-2.

ABSTRACT: The development of effective antiviral drugs against SARS-CoV-2 is urgently needed and a global health priority. In light of the initial data regarding the repurposing of hydroxychloroquine (HCQ) to tackle this coronavirus, herein we present a quantitative synthesis and spectroscopic and thermal characterization of seven HCQ room temperature ionic liquids (HCQ-ILs) obtained by direct protonation of the base with two equivalents of organic sulfonic, sulfuric and carboxylic acids of different polarities. Two non-toxic and hydrophilic HCQ-ILs, in particular, [HCQH₂][C₁SO₃]₂ and [HCQH₂][GlcCOO]₂, decreased the virus-induced cytopathic effect by two-fold in comparison with the original drug, [HCQH₂][SO₄]. De

SUBMITTER: Faisca F 

PROVIDER: S-EPMC9031298 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature