Current Knowledge on Mammalian Phospholipase A₁, Brief History, Structures, Biochemical and Pathophysiological Roles.

ABSTRACT: Phospholipase A₁ (PLA₁) is an enzyme that cleaves an ester bond at the sn-1 position of glycerophospholipids, producing a free fatty acid and a lysophospholipid. PLA₁ activities have been detected both extracellularly and intracellularly, which are well conserved in higher eukaryotes, including fish and mammals. All extracellular PLA₁s belong to the lipase family. In addition to PLA₁ activity, most mammalian extracellular PLA₁s exhibit lipase activity to hydrolyze triacylglycerol, cleaving the fatty acid and contributing to its absorption into the intestinal tract and tissues. Some extracellular PLA₁s exhibit PLA₁ activities specific to phosphatidic acid (PA) or phosphatidylserine (PS) and serve

SUBMITTER: Yaginuma S 

PROVIDER: S-EPMC9031518 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature