Deficiency of Thyroid Hormone Reduces Voltage-Gated Na⁺ Currents as Well as Expression of Na⁺/K⁺-ATPase in the Mouse Hippocampus.

ABSTRACT: Mice lacking functional thyroid follicular cells, Pax8^-/- mice, die early postnatally, making them suitable models for extreme hypothyroidism. We have previously obtained evidence in postnatal rat neurons, that a down-regulation of Na⁺-current density could explain the reduced excitability of the nervous system in hypothyroidism. If such a mechanism underlies the development of coma and death in severe hypothyroidism, Pax8^-/- mice should show deficits in the expression of Na⁺ currents and potentially also in the expression of Na⁺/K⁺-ATPases, which are necessary to maintain low intracellular Na⁺ levels. We thus compared Na⁺ current densities in postnatal mice using the patch-clamp technique

SUBMITTER: Sundaram SM 

PROVIDER: S-EPMC9031557 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature