NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia.

ABSTRACT: Approximately 1 in 10 newborns are born preterm and require supplemental oxygen (O₂) in an extrauterine environment following birth. Supplemental O₂ can induce oxidative stress that can impair mitochondrial function, resulting in lung injury and increased risk in early life pulmonary diseases. The nuclear factor-erythroid 2 related factor 2 (NRF2) protects the cells from oxidative stress by regulating the expression of genes containing antioxidant response elements and many mitochondrial-associated genes. In this study, we compared Nrf2-deficient (Nrf2^-/-) and wild-type (Nrf2^+/+) mice to define the role of NRF2 in lung mitochondrial genomic features in late embryonic development in mice (embryonic days, E13.5 and E18.5) versu

SUBMITTER: Vellers HL 

PROVIDER: S-EPMC9031618 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature