Immunological Evaluation of Goats Immunized with a Commercial Vaccine against Johne's Disease.

ABSTRACT: Johne's disease affects ruminants causing an economic burden to dairy, meat and wool industries. Vaccination against Mycobacterium avium subspecies paratuberculosis (Map), which causes Johne's disease, is a primary intervention for disease control in livestock. Previously, a comprehensive, multi-institutional vaccine trial for Johne's disease was conducted to test the efficacy of live attenuated Map strains. Here, we report the humoral and cell-mediated immune responses from kid goats enrolled in that trial. Both vaccinated and unvaccinated animals showed IFN-γ stimulation and proliferation of T cell subpopulations on challenge with Map. CD4+, CD25+ and γδ cells from cultured PBMCs in the vaccinated goats showed significantly greater proliferation respons

SUBMITTER: Bannantine JP 

PROVIDER: S-EPMC9031733 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature