Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm.

ABSTRACT: COVID-19-infected patients require an intact immune system to suppress viral replication and prevent complications. However, the complications of SARS-CoV-2 infection that led to death were linked to the overproduction of proinflammatory cytokines known as cytokine storm syndrome. This article reported the various checkpoints targeted to manage the SARS-CoV-2-induced cytokine storm. The literature search was carried out using PubMed, Embase, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. Journal articles that discussed SARS-CoV-2 infection and cytokine storm were retrieved and appraised. Specific checkpoints identified in managing SARS-CoV-2 induced cytokine storm include a decrease in the level of Nod-Like Receptor 3 (NLRP3) inflammasome where drugs such as quercet

SUBMITTER: Rabiu Abubakar A 

PROVIDER: S-EPMC9031737 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature