Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.

ABSTRACT: Patients with non-small cell lung cancer, especially adenocarcinomas, harbour at least one oncogenic driver mutation that can potentially be a target for therapy. Treatments of these oncogene-addicted tumours, such as the use of tyrosine kinase inhibitors (TKIs) of mutated epidermal growth factor receptor, have dramatically improved the outcome of patients. However, some patients may acquire resistance to treatment early on after starting a targeted therapy. Transformations to other histotypes-small cell lung carcinoma, large cell neuroendocrine carcinoma, squamous cell carcinoma, and sarcomatoid carcinoma-have been increasingly recognised as important mechanisms of resistance and are increasingly becoming a topic of interest for all specialists involved in the diagnosis, management, and c

SUBMITTER: Calabrese F 

PROVIDER: S-EPMC9031930 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature