Recent Advances in Treatment Options for Childhood Acute Lymphoblastic Leukemia.

ABSTRACT: Acute lymphoblastic leukemia is the most common blood cancer in pediatric patients. There has been enormous progress in ALL treatment in recent years, which is reflected by the increase in the 5-year OS from 57% in the 1970s to up to 96% in the most recent studies. ALL treatment is based primarily on conventional methods, which include chemotherapy and radiotherapy. Their main weakness is severe toxicity, which prompts dose reduction, decreases the effectiveness of the treatment, and, in some cases, can lead to death. Currently, numerous modifications in treatment regimens are applied in order to limit toxicities emerging from conventional approaches and improve outcomes. Hematological treatment of pediatric patients is reaching for more novel treatment options, such as targeted treatment,

SUBMITTER: Malczewska M 

PROVIDER: S-EPMC9032060 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature