An Approach to Quantifying the Interaction between Behavioral and Transmission Clusters.

ABSTRACT: We hypothesize that patterns of sexual behavior play a role in the conformation of transmission networks, i.e., the way you behave might influence whom you have sex with. If that was the case, behavioral grouping might in turn correlate with, and potentially predict transmission networking, e.g., proximity in a viral phylogeny. We rigorously present an intuitive approach to address this hypothesis by quantifying mapped interactions between groups defined by similarities in sexual behavior along a virus phylogeny while discussing power and sample size considerations. Data from the Swiss HIV Cohort Study on condom use and hepatitis C virus (HCV) sequences served as proof-of-concept. In this case, a strict inclusion criteria contrasting with low HCV prevalence hindered our possibilities to id

SUBMITTER: Salazar-Vizcaya L 

PROVIDER: S-EPMC9032082 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature