Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose.

ABSTRACT: The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor pharmacokinetic profile. Thus, we targeted the rational design and synthesis of trehalose-based small molecules and nano objects to overcome such issues. Among several rationally designed trehalose-centered putative autophagy inducers, we coupled trehalose via suitable spacers with known self-assembly inducer squalene to yield two nanolipid-trehalose conjugates. Squalene is known for its propensity, once linked to a bioactive compound, to assemble in aqueous media in controlled conditions, internalizing its payload and forming nanoassemblies with better pharmacokinetics. We assembled squalene conjugates to produce the corresponding nanoassembl

SUBMITTER: Frapporti G 

PROVIDER: S-EPMC9032118 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature