Targeted Printing of Cells: Evaluation of ADA-PEG Bioinks for Drop on Demand Approaches.

ABSTRACT: A novel approach, in the context of bioprinting, is the targeted printing of a defined number of cells at desired positions in predefined locations, which thereby opens up new perspectives for life science engineering. One major challenge in this application is to realize the targeted printing of cells onto a gel substrate with high cell survival rates in advanced bioinks. For this purpose, different alginate-dialdehyde-polyethylene glycol (ADA-PEG) inks with different PEG modifications and chain lengths (1-8 kDa) were characterized to evaluate their application as bioinks for drop on demand (DoD) printing. The biochemical properties of the inks, printing process, NIH/3T3 fibroblast cell distribution within a droplet and shear forces during printing were analyzed. Finally, different hydrog

SUBMITTER: Karakaya E 

PROVIDER: S-EPMC9032277 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature