RNase III Participates in the Adaptation to Temperature Shock and Oxidative Stress in Escherichia coli.

ABSTRACT: Bacteria thrive in ever-changing environments by quickly remodeling their transcriptome and proteome via complex regulatory circuits. Regulation occurs at multiple steps, from the transcription of genes to the post-translational modification of proteins, via both protein and RNA regulators. At the post-transcriptional level, the RNA fate is balanced through the binding of ribosomes, chaperones and ribonucleases. We aim to decipher the role of the double-stranded-RNA-specific endoribonuclease RNase III and to evaluate its biological importance in the adaptation to modifications of the environment. The inactivation of RNase III affects a large number of genes and leads to several phenotypical defects, such as reduced thermotolerance in Escherichia coli. In this study, we reveal that R

SUBMITTER: Lejars M 

PROVIDER: S-EPMC9032294 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature