Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease.

ABSTRACT: Epigenetic regulation of gene expression is necessary for maintaining higher-order cognitive functions (learning and memory). The current understanding of the role of epigenetics in the mechanism of Alzheimer's disease (AD) is focused on DNA methylation, chromatin remodeling, histone modifications, and regulation of non-coding RNAs. The pathogenetic links of this disease are the misfolding and aggregation of tau protein and amyloid peptides, mitochondrial dysfunction, oxidative stress, impaired energy metabolism, destruction of the blood-brain barrier, and neuroinflammation, all of which lead to impaired synaptic plasticity and memory loss. Ultrashort peptides are promising neuroprotective compounds with a broad spectrum of activity and without reported side effects. The main aim of this r

SUBMITTER: Ilina A 

PROVIDER: S-EPMC9032300 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature