The Evaluation of FGFR1, FGFR2 and FOXO1 in Orofacial Cleft Tissue.

ABSTRACT: Although cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies worldwide, the morphopathogenesis of non-syndromic orofacial clefts is still unclear. Many candidate genes have been proposed to play a causal role; however, only a few have been confirmed, leaving many still to be assessed. Taking into account the significance of FGFR1, FGFR2 and FOXO1 in embryogenesis, the aim of this work was to detect and compare the three candidate genes in cleft-affected lip and palatine tissue. Ten soft tissue samples were taken during cheiloplasty and veloplasty. The signals of the candidate genes were visualized using chromogenic in situ hybridization and analyzed using a semi-quantitative method. No statistically important difference in the d

SUBMITTER: Goida J 

PROVIDER: S-EPMC9032315 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature