Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.

ABSTRACT:

Introduction

Growth hormone (GH) deficiency (GHD) is often complicated by non-functioning pituitary tumors (NFPTs); however, its prevalence remains unclear because preoperative screening for GHD with provocative tests is not recommended. Accordingly, we attempted to clarify the characteristics of GHD in unoperated patients with NFPT.

Materials and methods

We retrospectively reviewed adult patients with non-functioning pituitary adenoma (NFPA) and Rathke's cyst who underwent preoperative GH-releasing peptide-2 (GHRP-2) tests from January 2013 to December 2016. We investigated the association between peak GH response to GHRP-2 and background characteristics.

Results

Among 104 patients (85 NFPA and 19 Rathke's cysts), 45 (43%) presented severe GHD, as diagnosed using GHR

SUBMITTER: Seki Y 

PROVIDER: S-EPMC9032366 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature