Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation.

ABSTRACT: The lager yeasts, Saccharomyces pastorianus, are hybrids of Saccharomyces cerevisiae and Saccharomyces eubayanus and are divided into two broad groups, Group I and II. The two groups evolved from at least one common hybridisation event but have subsequently diverged with Group I strains losing many S. cerevisiae chromosomes while the Group II strains retain both sub-genomes. The complex genomes, containing orthologous alleles from the parental chromosomes, pose interesting questions regarding gene regulation and its impact on the fermentation properties of the strains. Superimposed on the presence of orthologous alleles are complexities of gene dosage due to the aneuploid nature of the genomes. We examined the contribution of the S. cerevisiae and S. eubayanus alleles to the gene expressio

SUBMITTER: de la Cerda Garcia-Caro R 

PROVIDER: S-EPMC9032419 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature