Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs.

ABSTRACT: Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors may promote disease in individuals or subsequent progeny through epigenetic alterations. Variations in the epigenetic machinery cause a spectrum of different disorders since these mechanisms are more sensitive to the environmen

SUBMITTER: Olmedo-Suarez MA 

PROVIDER: S-EPMC9032613 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature