Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients.

ABSTRACT: Olfactory function, orchestrated by the cells of the olfactory mucosa at the rooftop of the nasal cavity, is disturbed early in the pathogenesis of Alzheimer's disease (AD). Biometals including zinc and calcium are known to be important for sense of smell and to be altered in the brains of AD patients. Little is known about elemental homeostasis in the AD patient olfactory mucosa. Here we aimed to assess whether the disease-related alterations to biometal homeostasis observed in the brain are also reflected in the olfactory mucosa. We applied RNA sequencing to discover gene expression changes related to metals in olfactory mucosal cells of cognitively healthy controls, individuals with mild cognitive impairment and AD patients, and performed analysis of the elemental content to determine m

SUBMITTER: Lampinen R 

PROVIDER: S-EPMC9032618 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature