Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy.

ABSTRACT: Despite advances in its treatment, heart failure remains a major cause of morbidity and mortality, evidencing an urgent need for novel mechanism-based targets and strategies. Myocardial hypertrophy, caused by a wide variety of chronic stress stimuli, represents an independent risk factor for the development of heart failure, and its prevention constitutes a clinical objective. Recent studies performed in preclinical animal models support the contribution of the Ca²⁺-dependent cysteine proteases calpains in regulating the hypertrophic process and highlight the feasibility of their long-term inhibition as a pharmacological strategy. In this review, we discuss the existing evidence implicating calpains in the development of cardiac hypertrophy, as well as the latest advances in unr

SUBMITTER: Aluja D 

PROVIDER: S-EPMC9032729 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature