Continuous Nanoprecipitation of Polycaprolactone in Additively Manufactured Micromixers.

ABSTRACT: The polymeric ouzo effect is an energy-efficient and robust method to create nanoparticles with biologically degradable polymers. Usually, a discontinuous or semi-continuous process is employed due to its low technical effort and the fact that the amount of dispersions needed in a laboratory is relatively small. However, the number of particles produced in this method is not enough to make this process economically feasible. Therefore, it is necessary to improve the productivity of the process and create a controllable and robust continuous process with the potential to control parameters, such as the particle size or surface properties. In this study, nanoparticles were formulated from polycaprolactone (PCL) in a continuous process using additively manufactured micromixers. The main goal

SUBMITTER: Gottert S 

PROVIDER: S-EPMC9032806 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature