Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis.

ABSTRACT: Linezolid is an efficacious medication for the treatment of drug-resistant tuberculosis but has been associated with serious safety issues that can result in treatment interruption. The objectives of this study were thus to build a population pharmacokinetic model and to use the developed model to establish a model-informed precision dosing (MIPD) algorithm enabling safe and efficacious dosing in patients with multidrug- and extensively drug-resistant tuberculosis. Routine hospital therapeutic drug monitoring data, collected from 70 tuberculosis patients receiving linezolid, was used for model development. Efficacy and safety targets for MIPD were the ratio of unbound area under the concentration versus time curve between 0 and 24 h over minimal inhibitory concentration (fAUC_0-

SUBMITTER: Mockeliunas L 

PROVIDER: S-EPMC9032906 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature