Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways.

ABSTRACT: Coronary artery disease (CAD) remains the leading cause of death despite scientific advances. Elucidating shared CAD/pneumonia pathways may reveal novel insights regarding CAD pathways. We performed genome-wide pleiotropy analyses of CAD and pneumonia, examined the causal effects of the expression of genes near independently replicated SNPs and interacting genes with CAD and pneumonia, and tested interactions between disruptive coding mutations of each pleiotropic gene and smoking status on CAD and pneumonia risks. Identified pleiotropic SNPs were annotated to ADAMTS7 and IL6R. Increased ADAMTS7 expression across tissues consistently showed decreased risk for CAD and increased risk for pneumonia; increased IL6R expression showed increased risk for CAD and decrea

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9032941 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature