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Electrochemical synthesis of quinazolinone via I₂-catalyzed tandem oxidation in aqueous solution.

ABSTRACT: The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I₂ in coordination with electrochemical synthesis induced a C-H oxidation reaction which is reported when using water as the environmentally friendly solvent to access a broad range of quinazolinones at room temperature. The reaction mechanism strongly showed that I₂ cooperates electrochemically promoted the oxidation of alcohols, then effectively cyclizing amides to various quinazolinones.

SUBMITTER: Hou H

PROVIDER: S-EPMC9033184 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Electrochemical synthesis of quinazolinone via I2-catalyzed tandem oxidation in aqueous solution.

Hou Huiqing H Ma Xinhua X Lin Yingying Y Lin Jin J Sun Weiming W Wang Lei L Xu Xiuzhi X Ke Fang F

RSC advances 20210517 29

The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I2 in coordination with electrochemical synthesis induced a C-H oxidation reaction which is reported when using water as the environmentally friendly solvent to access a broad range of quinazolinones at room temperature. The reaction mechanism strongly showed that I ...[more]

PMID: 35480173

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