Metagenomic sequencing reveals time, host, and body compartment-specific viral dynamics after lung transplantation.

ABSTRACT:

Background

The virome of lung transplant recipients (LTRs) under immunosuppressive therapy is dominated by non-pathogenic Anelloviridae and further includes several pathogenic viruses such as Herpesviruses or respiratory viruses. It is unclear whether the donor-derived virome in the transplanted lung influences recipient virome dynamics in other body compartments and if so, to which degree. Likewise, it is unknown whether dependencies exist among virus populations that mutually shape viral loads and kinetics.

Results

To address these questions, we characterized viral communities in airways and plasma of 49 LTRs and analyzed their abundance patterns in a data modeling approach. We found distinct viral clusters that were specific for body compartments and displayed independent

SUBMITTER: Widder S 

PROVIDER: S-EPMC9033415 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature