Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles.
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ABSTRACT:
SUBMITTER: Zou J
PROVIDER: S-EPMC9033439 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles.
Zou Jianmei J Gao Qian Q Nie Jinfang J Zhang Yun Y Jin Cheng C
RSC advances 20210521 30
In this work, phosphorylated lipid-conjugated oligonucleotide (DNA-lipid-P) has been synthesized to develop an enzyme-responsive self-assembly of DNA amphiphiles based on dephosphorylation-induced increase of hydrophobicity. Since elevated ALP level is a critical index in some diseases, ALP-triggered self-assembly of DNA amphiphiles shows promise in disease diagnosis and cancer treatment. ...[more]
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