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Metal-free multicomponent synthesis of novel macrocyclic tetrathiadienes with cyano and amino groups.

ABSTRACT: The first synthesis of 5,12-diamino-7,14-bis(aryl)-1,4,8,11-tetrathiacyclotetradeca-5,12-diene-6,13-dicarbonitriles was performed as a multicomponent macroheterocyclization of malononitrile, aryl aldehydes, and 1,2-ethanedithiol in the presence of a catalytic amount of triethylamine in ethanol. The structures of the obtained macroheterocycles were confirmed by spectral methods, X-ray diffraction, and MALDI TOF mass spectrometry.

SUBMITTER: Akhmadiev NS

PROVIDER: S-EPMC9033490 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Metal-free multicomponent synthesis of novel macrocyclic tetrathiadienes with cyano and amino groups.

Akhmadiev Nail S NS Mescheryakova Ekaterina S ES Akhmetova Vnira R VR Ibragimov Askhat G AG

RSC advances 20210525 31

The first synthesis of 5,12-diamino-7,14-bis(aryl)-1,4,8,11-tetrathiacyclotetradeca-5,12-diene-6,13-dicarbonitriles was performed as a multicomponent macroheterocyclization of malononitrile, aryl aldehydes, and 1,2-ethanedithiol in the presence of a catalytic amount of triethylamine in ethanol. The structures of the obtained macroheterocycles were confirmed by spectral methods, X-ray diffraction, and MALDI TOF mass spectrometry. ...[more]

PMID: 35478647

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