Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease.

ABSTRACT: In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such as Parkinson's disease (PD). Dopaminergic neurons have recently been identified in the enteric nervous system (ENS). While ENS dopaminergic neurons have been shown to degenerate in genetic mouse models of PD, analyses of their survival in enteric biopsies of PD patients have provided inconsistent results to date. In this context, this review seeks to highlight the distinctive and shared factors and properties that control the evolution of these two sets of dopaminergic neurons from neuronal precursors to aging neurons. Although their cellular sources and developmental times of origin differ, midbrain and ENS dopaminergic neurons express many

SUBMITTER: Chalazonitis A 

PROVIDER: S-EPMC9033791 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature