Long-term administration of fisetin was not as effective as short term in ameliorating IR injury in isolated rat heart.

ABSTRACT: The current study aims to determine the comparative efficacy of fisetin in reducing myocardial ischemia-reperfusion injury (IR) in isolated rat hearts when the drug was given either oral or intraperitoneal (ip) for short-term and long-term administration. Rats treated with fisetin (20 mg/kg-oral/ip) for short (30 min prior to surgery) and long (15 days prior to surgery followed by 1-day washout) duration were subjected to myocardial IR using Langendorf perfusion system. Hemodynamics, cardiac injury, mitochondrial functional assessment, and fisetin levels were estimated. Unlike the long-term administration of fisetin, the short-term treated-rat heart exhibited significant cardioprotection, measured via hemodynamic indices (RPP in mmHg × beats/min × 10 ^ 4: IR - 4 ± 0.1, FIPS - 2.49 ± 0.18,

SUBMITTER: Prem PN 

PROVIDER: S-EPMC9033933 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature