One-step-immunoassay of procalcitonin enables rapid and accurate diagnosis of bacterial infection.

ABSTRACT: Procalcitonin (PCT) (i.e. a precursor of calcitonin) attracts much attention as a reliable biomarker of bacterial infections because its concentration increases rapidly in the blood when bacterial infections occur in the body. Sepsis may occur due to indiscriminate and vigorous proliferation of infectious bacteria, and accordingly early diagnosis and treatment of bacterial infection are of crucial importance. However, current diagnostic methods for sepsis suffer from long assay time, multiple and complex assay steps, inaccuracy, and requirement of analytical equipments. The goal of this study is to develop an advanced one-step-immunoassay that enables quick and accurate diagnosis of sepsis through measuring the PCT concentration in patient sera, which is based on self-enhancement of

SUBMITTER: Oh JH 

PROVIDER: S-EPMC9034003 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature