Effects of conditioned medium obtained from human adipose-derived stem cells on skin inflammation.

ABSTRACT:

Introduction

Cell therapy using adipose-derived mesenchymal stem cells (ASCs) is a promising avenue of regenerative medicine for the treatment of various diseases. It has been considered that ASCs exert their therapeutic effects through the secretion of multiple factors that are critical for tissue remodeling or the suppression of inflammation. Recently, conditioned medium (CM) from ASCs that contains a complex of secreted factors has received attention as a cost-effective alternative to cell therapy.

Methods

We investigated the effects of CM obtained from ASCs (ASCs-CM) using human dermal fibroblasts (hDFs) and human epidermal keratinocytes with or without interleukin (IL)-1β and examined mRNA levels of marker genes. We also examined alterations in cell proliferation and mo

SUBMITTER: Yano F 

PROVIDER: S-EPMC9034017 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature