Photopolymerized poly(l-lactide-b-N-vinyl-2-pyrrolidone) network resists cell adhesion in situ.

ABSTRACT: A three-armed star-shaped poly(l-lactide) (PLLA) oligomer was synthesized using glycerol to ring-opening and polymerize l-lactide. The resultant oligomer introduced photoreactive groups at the terminal of PLLA chains by a coupling reaction with monoethyl fumarate (FAME). Photopolymerizable resin has been prepared by mixing PLLA 3-FAME, N-vinyl-2-pyrrolidone (NVP) as a reactive diluent and Irgacure 2959 as a photoinitiator. The PLLA 3-FAME/NVP cross-linked network could be formed by UV curing and was characterized through mechanical property tests, cytotoxicity experiments and cell adhesion experiments. In the dry state, Young's modulus and tensile strength of the network were significantly higher than those of pure PLLA formed by fused deposition modeling (FDM) printing, due to the

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9034047 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature