Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein.

ABSTRACT: Micelles formed by pluronic triblock copolymers are known to be a promising class of drug delivery vehicles. Quantitative mechanistic insights into the ability of pluronic micelles to improve the solubility of poorly water soluble drugs, encapsulation and delivery of hydrophilic drugs are not available. The current study evaluated the energetics of encapsulation of chemotherapeutic drugs gemcitabine, cytarabine, and hydroxyurea in pluronic F127 and F68 micelles. In addition, the interactions of the drugs released from pluronic micellar media with serum albumin, which is a major circulatory transport protein, and subsequent conformational changes have also been analyzed with the help of calorimetry and spectroscopy. All the drugs showed improved partitioning in F127 micelles, the extent of

SUBMITTER: Prasanthan P 

PROVIDER: S-EPMC9034178 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature