Spirocyclic derivatives as antioxidants: a review.

ABSTRACT: In recent years, spiro compounds have attracted significant interest in medicinal chemistry due to their numerous biological activities attributed primarily to their versatility and structural similarity to important pharmacophore centers. Currently, the development of drugs with potential antioxidant activities is of great importance since numerous investigations have shown that oxidative stress is involved in the development and progression of numerous diseases such as cancer, senile cataracts, kidney failure, diabetes, high blood pressure, cirrhosis, and neurodegenerative diseases, among others. This article provides an overview of the synthesis and various antioxidant activities found in naturally occurring and synthetic spiro compounds. Among the antioxidant activities reviewed are DP

SUBMITTER: Acosta-Quiroga K 

PROVIDER: S-EPMC9034179 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature