Discrimination between sialic acid linkage modes using sialyllactose-imprinted polymers.

ABSTRACT: Glycosylation plays an important role in various pathological processes such as cancer. One key alteration in the glycosylation pattern correlated with cancer progression is an increased level as well as changes in the type of sialylation. Developing molecularly-imprinted polymers (MIPs) with high affinity for sialic acid able to distinguish different glycoforms such as sialic acid linkages is an important task which can help in early cancer diagnosis. Sialyllactose with α2,6' vs. α2,3' sialic acid linkage served as a model trisaccharide template. Boronate chemistry was employed in combination with a library of imidazolium-based monomers targeting the carboxylate group of sialic acid. The influence of counterions of the cationic monomers and template on their interactions was invest

SUBMITTER: Mavliutova L 

PROVIDER: S-EPMC9034230 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature