Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review.

ABSTRACT: Tyrosinase is a multifunctional glycosylated and copper-containing oxidase that is highly prevalent in plants and animals and plays a pivotal role in catalyzing the two key steps of melanogenesis: tyrosine's hydroxylation to dihydroxyphenylalanine (DOPA), and oxidation of the latter species to dopaquinone. Melanin guards against the destructive effects of ultraviolet radiation which is known to produce considerable pathological disorders such as skin cancer, among others. Moreover, the overproduction of melanin can create aesthetic problems along with serious disorders linked to hyperpigmented spots or patches on skin. Several skin-whitening products which reduce melanogenesis activity and alleviate hyperpigmentation are commercially available. A few of them, particularly those obtained fr

SUBMITTER: Obaid RJ 

PROVIDER: S-EPMC9034236 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature