Active chemo-mechanical feedbacks dictate the collective migration of cells on patterned surfaces.

ABSTRACT: Recent evidence has demonstrated that, when cultured on micro-patterned surfaces, living cells can move in a coordinated manner and form distinct migration patterns, including flowing chain, suspended propagating bridge, rotating vortex, etc. However, the fundamental question of exactly how and why cells migrate in these fashions remains elusive. Here, we present a theoretical investigation to show that the tight interplay between internal cellular activities, such as chemo-mechanical feedbacks and polarization, and external geometrical constraints are behind these intriguing experimental observations. In particular, on narrow strip patterns, strongly force-dependent cellular contractility and intercellular adhesion were found to be critical for reinforcing the leading edge of the migratin

SUBMITTER: Fang C 

PROVIDER: S-EPMC9034249 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature