Interplay between Brownian motion and cross-linking controls bundling dynamics in actin networks.

ABSTRACT: Morphology changes in cross-linked actin networks are important in cell motility, division, and cargo transport. Here, we study the transition from a weakly cross-linked network of actin filaments to a heavily cross-linked network of actin bundles through microscopic Brownian dynamics simulations. We show that this transition occurs in two stages: first, a composite bundle network of small and highly aligned bundles evolves from cross-linking of individual filaments and, second, small bundles coalesce into the clustered bundle state. We demonstrate that Brownian motion speeds up the first stage of this process at a faster rate than the second. We quantify the time to reach the composite bundle state and show that it strongly increases as the mesh size increases only when the concentration

SUBMITTER: Maxian O 

PROVIDER: S-EPMC9034250 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature