Desmoglein 2 can undergo Ca²⁺-dependent interactions with both desmosomal and classical cadherins including E-cadherin and N-cadherin.

ABSTRACT: Desmoglein (Dsg) 2 is a ubiquitously expressed desmosomal cadherin. Particularly, it is present in all cell types forming desmosomes, including epithelial cells and cardiac myocytes and is upregulated in the autoimmune skin disease pemphigus. Thus, we here characterized the binding properties of Dsg2 in more detail using atomic force microscopy (AFM). Dsg2 exhibits homophilic interactions and also heterophilic interactions with the desmosomal cadherin desmocollin (Dsc) 2, and further with the classical cadherins E-cadherin (E-Cad) and N-cadherin (N-Cad), which may be relevant for cross talk between desmosomes and adherens junctions in epithelia and cardiac myocytes. We found that all homo- and heterophilic interactions were Ca²⁺-dependent. All binding forces observed are in the

SUBMITTER: Fuchs M 

PROVIDER: S-EPMC9034291 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature