Synthesis of indazoles from 2-formylphenylboronic acids.

ABSTRACT: A method for the synthesis of indazoles was developed which involves a copper(ii) acetate catalysed reaction of 2-formylboronic acids with diazadicaboxylates followed by acid or base induced ring closure. Hydrazine dicarboxylates were also shown as competent reaction partners for the synthesis of indazoles, however, they required a stoichiometric amount of copper(ii) acetate for the C-N bond formation step. The transformation can be efficiently performed as a two step-one pot procedure to give a range of 1N-alkoxycarbonyl indazoles.

SUBMITTER: Solomin VV 

PROVIDER: S-EPMC9034367 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature