Quantitative proteomic profiling of hepatocellular carcinoma at different serum alpha-fetoprotein level.

ABSTRACT:

Purpose

Hepatocellular carcinoma (HCC) is characterized by a poor long-term prognosis and high mortality rate. Serum alpha-fetoprotein (AFP) levels show great prognostic value in patients undergoing hepatectomy. This study aims to explore proteomic profiling in HCC samples based on AFP subgroups and identify potential key targets involved in HCC progression.

Methods

Twelve paired tumor and adjacent noncancerous tissue samples were collected from patients with HCC who underwent primary curative resection from January 2012 to December 2013. Clinical information was curated from four tissue microarrays to conduct survival analysis based on serum AFP levels. TMT-based quantitative proteomic analyses and bioinformatics analyses were performed to comprehensively profile molecular

SUBMITTER: Wei X 

PROVIDER: S-EPMC9034393 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature