Impact of HIV infection on overall survival among women with stage IV breast cancer in South Africa.

ABSTRACT:

Purpose

Advanced breast cancer (BC) at diagnosis is common in sub-Saharan Africa (SSA), including among women living with HIV (WLWH). In public hospitals across South Africa (SA), 10-15% of women present with stage IV BC, compared to < 5% in the United States (US); 20% of new BC diagnoses in SA are in WLWH. We evaluated the impact of HIV on overall survival (OS) among women with stage IV BC.

Methods

We conducted a prospective cohort study of women diagnosed with stage IV BC between February 2, 2015 and September 18, 2019 at six public hospitals in SA. Multivariate Cox regression models were used to estimate the association between HIV status and OS.

Results

Among 550 eligible women, 147 (26.7%) were WLWH. Compared to HIV-negative BC patients, WLWH were younger (median

SUBMITTER: Pumpalova YS 

PROVIDER: S-EPMC9034410 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature