Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies.

ABSTRACT: Systemic sclerosis is the rheumatic disease with the highest individual mortality. The severity of the disease is determined by the extent of fibrotic changes to cutaneous and internal organ tissues, the most life-threatening visceral manifestations being interstitial lung disease, SSc-associated-pulmonary arterial hypertension and myocardial involvement. The heterogeneity of the disease has initially hindered the design of successful clinical trials, but considerations on classification criteria have improved patient selection in trials, allowing the identification of more homogeneous groups of patients based on progressive visceral manifestations or the extent of skin involvement with a focus of patients with early disease. Two major subsets of systemic sclerosis are classically describe

SUBMITTER: Lescoat A 

PROVIDER: S-EPMC9034469 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature