Effects of intensive insulin therapy on the retinal microvasculature in patients with type 2 diabetes mellitus: a prospective observational study.

ABSTRACT:

Background

We examined the retinal microvascular changes and associated factors in type 2 diabetes mellitus (T2DM) before and after intensive insulin therapy.

Methods

This prospective observational study recruited patients with T2DM and divided them into intensive insulin therapy and oral hypoglycemic agent groups. All patients enrolled in this study had diabetes without retinopathy or non-proliferative diabetic retinopathy. Optical coherence tomography angiography (OCTA) was used in all patients before treatment and at 1, 3, and 6 months after treatment. Vessel density (VD) and thickness changes in the macular and optic disc areas were assessed.

Results

The study included 36 eyes in the intensive insulin therapy group and 36 in the oral hypoglycemic agent group. One

SUBMITTER: Yang N 

PROVIDER: S-EPMC9034536 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature