Analysis of GWAS-nominated loci for lung cancer and COPD revealed a new asthma locus.

ABSTRACT:

Background

Asthma, lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are three respiratory diseases characterized by complex mechanisms underlying and genetic predispositions, with asthma having the highest calculated heritability. Despite efforts deployed in the last decades, only a small part of its heritability has been elucidated. It was hypothesized that shared genetic factors by these three diseases could help identify new asthma loci.

Methods

GWAS-nominated LC and COPD loci were selected among studies performed in Caucasian cohorts using the GWAS Catalog. Genetic analyses were carried out for these loci in the Saguenay-Lac-Saint-Jean (SLSJ) asthma familial cohort and then replicated in two independent cohorts (the Canadian Cohort Obstructive Lung Disea

SUBMITTER: Madore AM 

PROVIDER: S-EPMC9034599 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature