Dexmedetomidine improved one-lung ventilation-induced cognitive dysfunction in rats.

ABSTRACT:

Background

One-lung ventilation (OLV) is widely used in thoracic surgery. However, OLV may also increase CERO₂ and aggravate delayed cognitive recovery. Here, we aimed to investigate the effect of dexmedetomidine (DEX) on cognitive function in rats undergoing OLV.

Methods

Sprague-Dawley rats were randomly divided into two-lung ventilation (TLV) group, OLV group and OLV treated with DEX group. Group DEX received 25 μg/kg DEX i.p. 30 min before induction. After mechanical ventilation (MV), Morris water maze (MWM) test was carried out to examine spatial memory function. Western blotting was used to detect pERK1/2, pCREB, Bcl-2 and BAX in hippocampal tissues. Transmission electron microscopy (TEM) was used to observe the hippocampal CA1 region.

Results

Post-MV,

SUBMITTER: Li M 

PROVIDER: S-EPMC9034634 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature