Gene interaction analysis of psoriasis in Chinese Han population.

ABSTRACT:

Background/aims

Psoriasis is a chronic immune-mediated inflammatory skin disease characterized by excessive proliferation of keratinocytes. It has a strong genetic predisposition; gene-gene interactions are important genetic models for common diseases. In this study, we explore pair-wise interactions among SNPs contributing to psoriasis susceptibility.

Methods

We first performed gene interactions with exome-sequencing, next, we analyzed gene interactions combining the exome sequencing data with the targeted sequencing data. After we sequenced HLA region, we analyzed gene interactions including HLA regions and non-HLA regions.

Results

We found interactions between HLA regions were significant. We observed significant interactions between HLA-C*06:02 and rs118179173 (sn

SUBMITTER: Xu Q 

PROVIDER: S-EPMC9034666 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature