Disentangling Signatures of Selection Before and After European Colonization in Latin Americans.

ABSTRACT: Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations. Through extensive simulations, we show that this method is able to detect selection, even in recently formed admixed populations, and to accurately differentiate between selection occurring in the ancestral or a

SUBMITTER: Mendoza-Revilla J 

PROVIDER: S-EPMC9034689 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature